Many garments are still made from polyester, even though it often makes people think of the disco era. Other clothing is lined with the fabric. However, synthetic fibers are those most likely to be the culprit when irritating skin. Sometimes polyester is blended with other materials, such as cotton, in clothing. This can sometimes allow you to wear it without a problem. That depends on your level of sensitivity, so just keep an eye out for problems when you wear polyester.